Both the parenchymal venous system and the glymphatic system participate in cerebral waste removal

讲座名称：Both the parenchymal venous system and the glymphatic system participate in cerebral waste removal

讲座人：胡伽尼教授

讲座时间：11月12日14:00

讲座地点：

线下：南校区C楼110

线上：腾讯会议直播（ID:106 264 335 密码：112233）

讲座人介绍：

胡伽尼，1990年博士毕业于美国范德比尔特大学物理化学专业，1990 - 1993年在美国费城福克斯癌症中心从事博士后研究。现为美国韦恩州立大学医学院放射系正教授，韦恩州立大学磁共振成像中心共同主任,磁共振成像生物医学研究所副所长, 卡尔曼诺癌症研究研究员, 国际神经血管疾病学会理事. 发表 SCI 论文 180 余篇, 3本著作/章节, 6800 Citations,h-index 45.

讲座内容：

Impaired cerebral waste clearance (CWC) has been associated with a broad range of both physiological and pathophysiological neurologic conditions, making it a focus-of-interest and an important area of study. Because of the unique anatomy of the brain parenchyma, theoretically, in the brain parenchyma, biochemically inert waste such as MRI contrast agents can only be removed through two possible pathways: cerebrospinal fluid (CSF) pathway, and/or vascular pathway. Despite controversy, there seems to be a solid consensus on the participation of the CSF pathway in CWC. In contrast to the CSF system, the current consensus is that parenchymal vascular system does not participate in CWC. Considering there is a big difference in flow rate between the blood (2 mL/min) and the CSF (3.7 ?L/min) and the brain is the most bioactive, energy-consuming organ (20% nutrition for about 5% of body weight) in the body, it is illogical that the brain would rely on the slow CSF circulation for CWC while less bioactive tissues outside the brain require both the fast vascular and slow lymphatic systems (which has the similar circulation speed as CSF) to remove waste in a timely manner. Here we present our results to demonstrate the participation of the parenchymal venous system in CWC using the qualitative and quantitative superparamagnetic iron oxide (SPIO)-enhanced susceptibility weighted imaging (SWI), SPIO-SWI methods.

主办单位：生命科学技术学院