有机光学探针在余晖成像和疾病监测中的应用

讲座名称：有机光学探针在余晖成像和疾病监测中的应用

讲座时间：2020-07-24 14:30

讲座人：浦侃裔

讲座地点：腾讯会议直播（ID：728 765 427）

讲座人介绍：

浦侃裔，博士，现任新加坡南洋理工大学化学与生物医学工程学院副教授（终生教职），工学院助理部长，web of science高被引学者。本科、硕士毕业于华东理工大学和复旦大学；2011年于新加坡国立大学获得博士学位，同年加入斯坦福大学医学院从事博士后研究工作。研究兴趣主要集中于基于有机半导体材料的生物光子学。已发表高水平SCI论文170多篇 （IF>10的112篇），著作3章，专利6项，H因子为69。获得多项奖项，包括2020 Biomaterials Science Lectureship Award, 2019 highly cited researcher,日本化学会杰出报告奖、威利生物科学贡献奖、青年学者旅游奖和纳米生物技术青年创新奖等。浦教授担任ACS Applied Polymer Materials 和Biomaterials Research副主编，Nano Research期刊Young Star主编，中美纳米医学与纳米生物技术学会(CASNN)理事会成员，Advanced Functional Materials, Bioconjugate Chemistry, ACS Applied Bio Materials, Advanced Biosystems, Journal of Nanobiotechnology和ChemNanoMat等期刊编委。

讲座内容：

Optical imaging plays a crucial role in biology and medicine. However, the need for real-time light excitation during imaging produces tissue autofluorescence, and thus compromises imaging sensitivity and specificity. Meanwhile, optical agents are often retained in living bodies, posing additional toxicity issue. In this talk, I will introduce molecular afterglow reporters with long-lasting luminescence after removal of light excitation for ultrasensitive in vivo imaging, followed by discussion on how to design renal-clearable optical reporters for early diagnosis of kidney diseases. The in vivo afterglow of SPNs has the signal to background ratio more than two orders of magnitude higher than NIR fluorescence, enabling rapid detection of tiny peritoneal metastatic tumors. The structural diversity of SPNs allows them to monitor temperature during photothermal cancer therapy and detect biomarkers of interest in living mice. To detect acute kidney injury (AKI), molecular renal probes (MRPs) with high renal clearance efficiency are developed. MRPs specifically activate their NIR/chemiluminescence signals towards the prodromal biomarkers of AKI, enabling the first example of longitudinal imaging of multiple molecular events in the kidneys of living mice. MRPs also act as exogenous tracers for optical urinalysis that outperforms typical clinical/preclinical assays. These studies thus provide the basis for an entirely new class of molecular optical reporters with ultrahigh sensitivity and high translational potential for early diagnosis.

主办单位：生命科学技术学院